Psoriasis is an autoimmune disease in which different parts of the body are affected including. As a result of this excessive skin production red and dry patches are formed on the skin in any part of the body ad are called psoriatic plaques. Some common parts where these patches can form are elbows and the knees. One condition of psoriasis in which toenails and fingernails are affected are and toenails is called psoriatic nail dystrophy. About two percent of the population all over the sufferers from this disease called psoriasis.
Life of a psoriasis sufferer is full of mild to severe episodes of symptoms which can sometime flare up. If the case is mild then the skin has faint reddish tinge, and it forms thick scaly plaques in severe cases which covers the whole body. As per most medical researchers both the factors i.e. genetic and environmental factors play a role in developing psoriasis. There are some cases in which alcohol smoking and stress can act as a triggering factor for developing psoriasis.
Majority of psoriasis sufferers opt for Methotrexate psoriasis therapy when there is no improvement with other treatment options. For example, when application of ointments and creams do not respond in case of psoriasis sufferers then phototherapy and photochemotherapy may be used.
If topical treatment and phototherapy do not improve the condition of psoriasis then, then systemic treatment – potentially toxic medicines – usually prescribed. Usually systemic medications are administered by either injection, or in the form of oral pills. In the category of systemic treatment Methotrexate psoriasis therapy is the popular one. In this treatment the patient is given the Methotrexate pills – referred to as an immunosuppressant of folic acid analogue.
As a result of this treatment skin cells product is lowered which in turn reduces the immune system’s response so the inflammation decreases too. Also for slowing the progression of psoriatic arthritis the Methotrexate psoriasis therapy is very effective. You can learn more here.
Even though it is considered as the popular psoriasis treatment, there are potential risks and side effects involved that can be harmful for health. For example if it is taken in a high dose then it can result in stomach cramps as well as loss of appetite.
The effect of this drug is mainly on the immune system of the body, so it can disturb the natural healing property or mechanism. So the body becomes more susceptible to infectious diseases or infections if the use of Methotrexate is prolong. There are some other side effects too that are caused by Methotrexate psoriasis therapy including stomach ulcer, high blood pressure, weak immune system, liver and kidney cell damage and fluctuation in blood glucose level.
So in order to stay away from long-term side effects that care caused by Methotrexate psoriasis therapy it is important to prescribe rotational therapy. After taking this drug for six to twelve months, it is important to replace it by a less toxic medicine – this can result in reduced damage to other parts of the body.